Risk of invasive MDRO infection in MDRO-colonized patients

This study aimed to estimate the risk of developing clinical multidrug-resistant organism (MDRO) infection in colonized patients compared to non-colonized patients in high-risk areas. A retrospective cohort study was conducted at a tertiary care facility, focusing on CRE colonization/infection. Results showed that colonization increased the risk of infection in the three cohorts (CRE, MRSA, and VRE), with a high percentage of matches between carbapenemase genes. The study suggests that screening results can inform infection management and treatment.